CELL-MEDIATED IMMUNITY IN PATIENTS WITH CERVICAL CANCER ON IMMUNOTHERAPY
Abstract
A total of 37 patients with stage III cervical cancer were examined to determine specific features in contents of blood and tumor tissue immunocompetent cells in cervical cancer patients receiving immunotherapy. The females were divided into 2 groups depending on receiving radiotherapy or combined radio- and immunotherapy by reinfusion of in vitro activated autolymphocytes plus recombinant interleukin-2 and Flogenzyme. Changes in contents of some lymphocyte differentiation clusters in blood and tumor biopsies were studied during treatment. After treatment completion the immunotherapy group demonstrated a statistically significant increase in levels of lymphocytes and their populations in blood and tumor tissue. Increase in cytotoxic lymphocyte levels was most marked which was suggestive of activation of antitumor immunity mechanisms.
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