SURGICAL METHODS FOR MORPHOLOGICAL ASSESSMENT OF PARASTERNAL LYMPH NODE STATUS AS A PART OF CONSERVATION TREATMENT IN BREAST CANCER PATIENTS

  • Victor Alexeyevich Uymanov Carcinogenesis Research Institute, N. N. Blokhin RCRC, RAMS
  • Mikhail Ivanovich Nechushkin Carcinogenesis Research Institute, N. N. Blokhin RCRC, RAMS
  • Arkadiy Vyacheslavovich Trigolosov Carcinogenesis Research Institute, N. N. Blokhin RCRC, RAMS
  • Alexander Valerievich Petrovskiy I. M. Sechenov First MSMU
  • Yana Vladimirovno Vishnevskaya Carcinogenesis Research Institute, N. N. Blokhin RCRC, RAMS
  • Anna Alexandwvna Zaitseva I. M. Sechenov First MSMU
Keywords: breast cancer, videothoracoscopy, parasternal lymphadenectomy

Abstract

The purpose of this study was to compare diagnostic capacity of videothoracoscopic parasternal lemphadenectomy and open lymph node biopsy in detection of parasternal lymph node involvement and frequency of complications after use of these approaches. The study was performed on a population of 884 women with stage I— IIB breast cancer receiving conservation treatment at the Radiosurgery Department, N. N. BlokhinRCRC, RAMS, during 1990 through 2005. Openbiopsyofparasternallymph nodes on theaffected side was made in 1 25 and videothoracoscopic parasternal lymphadenectomy was made in 759 of the 884 patients.
By logistic regression analysis, videothoracoscopic parasternal lymphadenectomy provides a 2.5-fold higher chance to detect parasternal lymph node metastases as compared to open biopsy (p = 0.018). Complications were reported in 1.6% of cases following open biopsy versus 1.2% after videothoracoscopic parasternal lymphadenectomy (p = 0.1). As compared to biopsy, videothoracoscopic parasternal lymphadenectomy is a surgical intervention of choice ensuring more objective information on the status of the lymph nodes in question and associated with a lower frequency of complications.

Author Biographies

Victor Alexeyevich Uymanov, Carcinogenesis Research Institute, N. N. Blokhin RCRC, RAMS

MD, PhD, Senior Researcher, Radiosurgery Department
N. N. Blokhin RCRC, RAMS
(24, Kashirskoye sh., Moscow, RF, 115478)

Mikhail Ivanovich Nechushkin, Carcinogenesis Research Institute, N. N. Blokhin RCRC, RAMS

MD, PhD, DSc, Professor, Head, Radiosurgery Department
N. N. Blokhin RCRC, RAMS
(24, Kashirskoye sh., Moscow, RF, 1 15478)

Arkadiy Vyacheslavovich Trigolosov, Carcinogenesis Research Institute, N. N. Blokhin RCRC, RAMS

MD, PhD, Senior Researcher, Radiosurgery Department
N. N. Blokhin RCRC, RAMS
(24, Kashirskoye sh., Moscow, RF, 115478)

Alexander Valerievich Petrovskiy, I. M. Sechenov First MSMU

MD, PhD, Associate Professor, Chair of Oncology, Treatment Faculty
I. M. Sechenov First MSMU
(8/2, ul. Trubetskaya, Moscow, 1 19991, RF)

Yana Vladimirovno Vishnevskaya, Carcinogenesis Research Institute, N. N. Blokhin RCRC, RAMS

MD, PhD, Senior Researcher, Human Tumor Pathological Anatomy Department,
N. N. Blokhin RCRC, RAMS
(24, Kashirskoye sh., Moscow, RF, 1 15478)

Anna Alexandwvna Zaitseva, I. M. Sechenov First MSMU

Postgraduate Student, Chair of Oncology, Treatment Faculty
I. M. Sechenov First MSMU
(8/2, ul. Trubetskaya, Moscow, 119991, RF)

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Published
2012-08-01
Section
Clinical studies