INFLUENCE OF DIFFERENT KINDS OF POLYMERIC ENDOPROSTHESES, USED FOR INGUINAL HERNIOPLASTY, ON FERTILITY OF EXPERIMENTAL ANIMALS

Abstract

The experiment on 21 white male rats and 84 pregnant white female rates was carried out to investigate potential effect of inguinal hernioplasty using alloplastic materials on fertility of white male rats and possible embryotoxicity of the endoprostheses.

Two experimental, one control and one intact group were formed of male rates. Operation of double-sided hernioplasty using polypropylene endoprosthesis was modeled in the first group (n=6). In the second group (n=5) double-sided hernioplasty using polytetrafluorethylene endoprosthesis was modeled. Hernioplasty in male rats of control group (n=5) was modeled without using endoprosthesises, the plasty was carried out with caproic filament. Male rates of intact group (n=5) did not undergo any surgery.

The male rats of experimental groups were mated with intact female rats to detect the influence of inguinal hernioplasty using alloplastic materials on fertility of male rates and possible embryotoxic action of implants. The male rats of intact group were mated with intact females as well.

Results of the research indicate the absence of negative effect of inguinal hernioplasty method using alloplastic materials on fertility of the white male rats and the absence of endoprostheses embryotoxicity.