MORPHOFUNCTIONAL PROPERTIES OF THE COLON IN THE 15-DAY INFANT RATS DEVELOPING IN CHOLESTASIS OF MOTHER

  • Ya. R. Matsyuk Educational Establishment «Grodno State Medical University»
  • E. Ch. Mikhalchuk Educational Establishment «Grodno State Medical University»
  • E. A. Shelesnaya Educational Establishment «Grodno State Medical University»
Keywords: pregnancy, cholestasis, offspring, colon.

Abstract

The experimental study of 16 female rats and their 19 infants by histological, cytochemical methods with the subsequent morphometric, cytophotometric and statistical analysis showed that subhepatic obstructive cholestasis simulated on the 17th day of pregnancy caused delayed development of colonic wall membranes and the formation of folds and crypts in the 15-day offspring. Decrease in the activity of succinate dehydrogenase, NADH dehydrogenase and elevation of lactic dehydrogenase in the superficial epithelial cells indicates the disturbed energy metabolism that leads to the inhibition of cell differentiation and synthetic processes in the cells. The latter is confirmed by the decrease in glycoproteins and sialomusines in the epithelial cells.

Published
2017-10-17
Issue
No. 2(42) (2013): Journal of the Grodno State Medical University
Section
ORIGINAL STUDIES