MARKERS OF BONE TISSUE METABOLISM AND THEIR CLINICAL SIGNIFICANCE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

The data of present study have provided evidence to assert that bone metabolism impairment in COPD patients are characterized by a vitamin D deficiency, suppression of type I procollagen propeptides and osteocalcin production, increased в-C-terminal telopeptides of type I collagen and parathyroid hormone synthesis. The intensity of these changes has a direct correlation to the stage of COPD and the presence of harmful habits.