SIGNIFICANCE OF THE LEVELS OF BIOGENIC AMINES, THEIR PRECURSORS AND METABOLITES IN THE DIFFERENTIAL DIAGNOSIS OF MENINGEAL SYNDROME

  • T.V. Liopo Educational Establishment “Grodno State Medical University”
  • Ye.M. Doroshenko Educational Establishment “Grodno State Medical University”
Keywords: biogenic amines, meningitis, CSF, diagnosis

Abstract

Aim of study: optimization of differential diagnosis of meningeal syndrome (MS).

The levels of biogenic amines, their precursors and metabolites in the cerebrospinal fluid of patients with acute respiratory viral infections with MS, serous and purulent meningitis were investigated. Purulent meningitis was found to be characterized by an increase of CSF levels of aromatic amino acids. The CSF level of serotonin in patients with meningitis (both purulent and serous) was higher than in patients with acute respiratory viral infections and MS. The content of DOPA in patients with serous meningitis was significantly lower than in patients with purulent meningitis.

Shifts in the CSF concentrations of biogenic amines and related compounds were found to be useful as additional criteria for the differential diagnosis of MS.

Published
2015-08-03
Issue
No. 2(42) (2013): Journal of the Grodno State Medical University
Section
ORIGINAL STUDIES