EXPERIMENTAL MODELS FOR STUDYING DIABETES MELLITUS PART 1. ALLOXAN DIABETES

Abstract

The literature data on the model of alloxan-induced diabetes in experimental animals have been summarized in the review. The mechanisms of selectivе action of alloxan on the в-cells of the pancreas have been analyzed and discussed as well. It can be concluded, that the interaction of various biological effects produced by alloxan is the basis of the pathogenesis of experimental diabetes.