EFFECT OF THYROID STATUS CHANGE ON ENZYMATIC AND NON-ENZYMATIC COMPONENTS OF THE ANTIOXIDANT SYSTEM UNDER THE INFLUENCE OF DIFFERENT NATURE STRESSORS

Abstract

During the experiments on 130 white outbreed male rats it was found that experimental hypothyroidism (25mg/kg of merkazolil within 20 days) stimulates, whereas small doses of L-thyroxin (1.5-3.0 mcg/kg within 28 days) limit the intensification of lipid peroxidation in the myocardium at physical (t 4-50C within 30 min), chemical (introduction of 25% ethanol solution in the dosage of 3.5 g/kg of body mass) and emotional (swimming of the animals in the cage during 30 min) stress due to the influence on the activity of fermentative and non-fermentative components of the antioxidant system.