MORPHOLOGICAL SKIN CHANGES AT THERMAL BURN IN INFANT RATS UNDER THE CONDITIONS OF CORRECTION BY INTRAVENOUS LASER RADIATION OF BLOOD AND EMOKSIPIN

Abstract

The aim. To assess the effect of emoxipine, intravenous laser radiation of blood and their combinations on morphological changes of a burn wound in 30-days infant rats. The experiment was performed on male infant rats weighing 55-65 g at the age of 30 days, n = 25. Specially developed device created a thermal burn of skin with hot liquid (water) of 99-100 °C (10 sec exposure) in infant rats. For the treatment we used 1% emoxipine solution (10 days) and intravenous laser radiation of blood (0.67 microns, radiation capacity on the end of the light guide of 1.5-2.0 MW, time of the first session of laser radiation was 5 min, at subsequent 4 sessions – 6 min). Histological preparations were stained with hematoxylin and eozin. When using emoxipine, intravenous laser radiation of blood and their combinations the reduction of purulent inflammation in a wound, spread of purulent infiltrate in a wound, as well as the increase in the density of the neogenic vessels providing microcirculation of blankets of granulations and reparation processes in general are observed.