DYNAMICS OF LEVELS OF PLASMA HOMOCYSTEINE AND ITS METABOLITES IN PATIENTS WITH POST-MYOCARDIAL INFARCTION DEPRESSION UNDERGOING THERAPY

  • E.M. Surmach Educational Establishment «Grodno State Medical University»
  • V.A. Snezhitskiy Educational Establishment «Grodno State Medical University»
  • A.V. Navumau Educational Establishment «Grodno State Medical University»
Keywords: myocardial infarction, depression episode, homocysteine, tryptophan, paroxetine, omacor

Abstract

The aim of the study was to assess the effect of medication on the levels of homocysteine (Hcy) and its metabolites in blood plasma of patients with depressive episodes in post-infarction period. The levels of sulphur-containing compounds in blood plasma were determined in 132 patients with sustained myocardial infarction (MI) and depression episodes of various severities and without depression. The administration of tryptophan (Trp) and omacor is associated with the decrease in the level of Hcy; paroxetine and «basic» treatment showed no effect on the level of Hcy plasma concentration. Correlations between the levels of cholesterol, cholesterol of low density lipoproteins, plasma concentrations of Trp, 5-hydroxyindoleacetic acid (5-HIAA) and the level of Hcy have been found.

Published
2015-08-05
Issue
No. 3(43) (2013): Journal of the Grodno State Medical University
Section
ORIGINAL STUDIES